Neuroregeneration and innate immunity

Jorg Mey

Neuroregeneration and innate immunity


Principal investigator: Dr Jörg Mey




The Nerve Regeneration group will establish its laboratory in the new research building of the National Hospital for Paraplegics. Meanwhile we carry out projects at the Institute of Zoology of the RWTH Aachen, Germany, with funding from the German national research foundation.


We follow two main lines of research:


1.- Study of the role of nuclear receptors in the spinal cord injury and other pathologic conditions with consequences of neuro-degeneration


2.- Development of artificial implants for peripheral nerve regeneration


Academic teaching has always played an important role among the group's activities. The principal investigator is a professor at the RWTH Aachen, Germany, and the director of the European Master of Neuroscience program based at the University of Maastricht, Netherlands []. 





Selected publications


- Sukiban J, Braunig P, Mey J, Bui-Gobbels K. Retinoic acid as a survival factor in neuronal development of the grasshopper, Locusta migratoria. Cell Tissue Res. 2014; 358 (2): 303-312. doi: 10.1007/s00441-014-1957-y.


- Kriebel A, Rumman  M, Scheld M, Hodde D, Brook G, Mey J. Three-dimensional configuration of orientated fibers as guidance structures for cell migration and axonal grwoth. J Biomed Mater Res B Appl Biomater. 2014;102(2):356-65. doi: 10.1002/jbm.b.33014.


- Koopmans GC, Deumens R, Honig W, Hamers FPT, Mey J, van Kleef M, Joosten EAJ. Functional recovery, serotonergic sprouting and endogenous progenitor fates in response to delayed environmental enrichment after spinal cord injury. J. Neurotrauma, 2012; 29: 514-527.


- Kampmann E, Johann S, van Neerven S, Beyer C, Mey J. Anti-inflammatory effect of retinoic acid on prostaglandin synthesis in cultured cortical astrocytes. J. Neurochem. 2008; 106: 320-332.


- Schnell E, Klinkhammer K, Balzer S, Brook G, Klee D, Dalton P, Mey J. Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-ε-caprolactone and a collagen/poly-ε-caprolactone blend. Biomaterials, 2007; 28: 3012-3025.






Andreas Kriebel: predoctoral student; MSc in Biology (RWTH Aachen) and MSc in Cognitive and Clinical Neuroscience (Maastricht University).


Current external collaborations:

Peter McCaffery. University of Aberdeen, Scotland, UK.

Gary Brook. University Hospital of the RWTH Aachen, Germany

Cordian Beyer. University Hospital of the RWTH Aachen, Germany.

Fred van Leeuwen. Maastricht University, Netherlands




Research lines


- Study of nuclear receptor signaling after spinal cord injury and in neurodegenerative diseases.


- Development of artificial implants for peripheral nerve regeneration.


- Investigation of the development of topographic maps in the visual system: role of retinoid signaling.